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The traditional methods of drug reconstitution involve manual extraction and transfer of diluent for mixing the drug. As such, these methods are complex and associated with several concerns including, large number of steps, multiple containers, and medications errors, which made reconstitution of various lyophilized drugs and vaccines a challenge in commercialization of these drugs. This has led to the development of novel drug reconstitution systems, which enable simple and effective way of reconstitution and administration of lyophilized products.
VDAs target the endothelial cells of tumor blood vessel that are involved in processes like migration, adhesion, cohesion, and proliferation which further alternates the shape of the endothelial cells, break the cell-to-cell junctions, thereby, leading to loss of cohesion and ultimately resulting in ischemia and tumor necrosis. They have shown greatest effect in combination with conventional chemotherapy or other modes of treatment that selectively target and attack cancer cells. Presently, there are multiple small molecule VDAs, which have been / are being developed for the treatment of a variety of oncological conditions, including colorectal cancer, glioblastoma, hepatocellular carcinoma, lung cancer, melanoma and ovarian cancer.
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